Browsing Toxins
Displaying toxin 2851 - 2875 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D4292 | Orotic acid 65-86-1 | C5H4N2O4 156.096 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4204 | Mechlorethamine 51-75-2 | C5H11Cl2N 156.054 g/mol |  |
| Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their atte...more Number of Targets: 1 |
| T3D1492 | Aluminium carbide 1299-86-1 | C3H12Al4 156.054 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D1476 | Zinc formate 557-41-5 | C2H2O4Zn 155.444 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D4060 | Retronecine 480-85-3 | C8H13NO2 155.194 g/mol |  |
| Retronecine is classified as a pyrrolizidine alkaloid (PA). Unsaturated pyrrolizidine alkaloids are hepatotoxic, that is, damaging to the liver. PAs also cause hepatic...more Number of Targets: 0 |
| T3D4675 | Arecoline 63-75-2 | C8H13NO2 155.194 g/mol |  |
| Arecoline is the primary active ingredient responsible for the central nervous system effects of the areca nut. Arecoline has been compared to nicotine; however, nicot...more Number of Targets: 4 |
| T3D4363 | L-Histidine 71-00-1 | C6H9N3O2 155.155 g/mol |  |
| Since the actions of supplemental L-histidine are unclear, any postulated mechanism is entirely speculative. However, some facts are known about L-histidine and some o...more Number of Targets: 5 |
| T3D1670 | Methacryloyloxyethyl isocyanate 30674-80-7 | C7H9NO3 155.151 g/mol |  |
| Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ...more Number of Targets: 39 |
| T3D0669 | Cobalt sulfate 10124-43-3 | CoO4S 154.996 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D1826 | Selenium tetrafluoride 13465-66-2 | F4Se 154.950 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 0 |
| T3D1451 | Chromyl chloride 14977-61-8 | Cl2CrO2 154.901 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D1859 | Antimony monosulfide 12067-17-3 | HSSb 154.830 g/mol |  |
| The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes ...more Number of Targets: 20 |
| T3D0697 | Nickel sulfate 7786-81-4 | NiO4S 154.756 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 68 |
| T3D4656 | P-Chloroacetophenone 99-91-2 | C8H7ClO 154.594 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4659 | a-Chloroacetophenone 532-27-4 | C8H7ClO 154.594 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D4838 | beta-Geraniol 106-24-1 | C10H18O 154.249 g/mol |  |
| Not Available Number of Targets: 4 |
| T3D4191 | 4-Decenal 30390-50-2 | C10H18O 154.249 g/mol |  |
| Uremic toxins such as 4-Decenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimula...more Number of Targets: 3 |
| T3D0389 | Biphenyl 92-52-4 | C12H10 154.208 g/mol |  |
| Biphenyl alters the permeability properties of mitochondrial membranes (A279). Number of Targets: 5 |
| T3D0161 | Acenaphthene 83-32-9 | C12H10 154.208 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D3661 | Patulin 149-29-1 | C7H6O4 154.120 g/mol |  |
| Patulin's strong affinity to sulfhydryl groups enables to to inhibit a number of enzymes, including succinate dehydrogenase, alcohol dehydrogenases, ATPases, acetylcho...more Number of Targets: 77 |
| T3D3969 | Diethylphosphate 598-02-7 | C4H11O4P 154.102 g/mol |  |
| S-Ethylisothiouronium diethylphosphate is a specific inhibitor of inducible NO synthase on hepatic NO production level. S-Ethylisothiouronium diethylphosphate affects ...more Number of Targets: 1 |
| T3D0047 | Carbon tetrachloride 56-23-5 | CCl4 153.823 g/mol |  |
| Unmetabolized carbon tetrachloride, depresses the central nervous system. All other toxic effects of carbon tetrachloride are related to its biotransformation via cyto...more Number of Targets: 40 |
| T3D1226 | Copper formate 544-19-4 | C2H2CuO4 153.581 g/mol |  |
| Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec...more Number of Targets: 6 |
| T3D1117 | Barium oxide 1304-28-5 | BaO 153.326 g/mol |  |
| Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to...more Number of Targets: 21 |
| T3D4300 | Dopamine 51-61-6 | C8H11NO2 153.178 g/mol |  |
| Dopamine is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system. Dopamine produces posi...more Number of Targets: 15 |