Browsing Toxins
Displaying toxin 2651 - 2675 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D0116 | 1,2,3-Trichlorobenzene 87-61-6 | C6H3Cl3 181.447 g/mol |  |
| Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent...more Number of Targets: 42 |
| T3D0200 | 1,2,4-Trichlorobenzene 120-82-1 | C6H3Cl3 181.447 g/mol |  |
| Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent...more Number of Targets: 39 |
| T3D0279 | Arsenic trichloride 7784-34-1 | AsCl3 181.281 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D2820 | Pyridostigmine 155-97-5 | C9H13N2O2 181.211 g/mol |  |
| Pyridostigmine is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholin...more Number of Targets: 2 |
| T3D2853 | Acamprosate 77337-76-9 | C5H11NO4S 181.210 g/mol |  |
| The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal ...more Number of Targets: 7 |
| T3D4371 | L-Tyrosine 60-18-4 | C9H11NO3 181.189 g/mol |  |
| Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the...more Number of Targets: 5 |
| T3D0812 | Glufosinate 51276-47-2 | C5H12NO4P 181.127 g/mol |  |
| Glufosinate irreversibly inhibits the enzyme glutamine synthetase, which decreases ammonia detoxification. Increased ammonia levels lead to impairment of photorespirat...more Number of Targets: 1 |
| T3D1377 | Basic beryllium carbonate 66104-24-3 | C2H2Be3O8 181.069 g/mol |  |
| Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a m...more Number of Targets: 3 |
| T3D0688 | Nickel chromate 14721-18-7 | CrH6NiO4 180.735 g/mol |  |
| Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promot...more Number of Targets: 73 |
| T3D4815 | 1,10-Phenanthroline 66-71-7 | C12H8N2 180.205 g/mol |  |
| Not Available Number of Targets: 6 |
| T3D3979 | Propylparaben 94-13-3 | C10H12O3 180.201 g/mol |  |
| Not Available Number of Targets: 3 |
| T3D4780 | Theophylline 58-55-9 | C7H8N4O2 180.164 g/mol |  |
| Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, an...more Number of Targets: 9 |
| T3D3886 | Monomethyl phthalate 4376-18-5 | C9H8O4 180.157 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D4201 | Caffeic acid 331-39-5 | C9H8O4 180.157 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D2936 | Aspirin 50-78-2 | C9H8O4 180.157 g/mol |  |
| The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molec...more Number of Targets: 18 |
| T3D4345 | D-Fructose 53188-23-1 | C6H12O6 180.156 g/mol |  |
| Fructose is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the generation of uric acid. Uric acid is generate...more Number of Targets: 5 |
| T3D4356 | D-Glucose 50-99-7 | C6H12O6 180.156 g/mol |  |
| Very high serum levels of glucose are found in untreated diabetic (type I or type II) patients. Glucose in chronic excess causes toxic effects on the structure and fun...more Number of Targets: 33 |
| T3D1398 | Cyclopentadienylcobalt dicarbonyl 12078-25-0 | C7H5CoO2 180.047 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 35 |
| T3D0297 | Potassium arsenate 7784-41-0 | AsH2KO4 180.033 g/mol |  |
| Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more Number of Targets: 44 |
| T3D1430 | Chromium carbide 12012-35-0 | C2Cr3 180.010 g/mol |  |
| Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, ch...more Number of Targets: 5 |
| T3D1469 | Sodium zincate 12179-14-5 | H4Na2O4Zn 179.418 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D2967 | Memantine 19982-08-2 | C12H21N 179.302 g/mol |  |
| Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased l...more Number of Targets: 8 |
| T3D0633 | Acridine 260-94-6 | C13H9N 179.217 g/mol |  |
| The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more Number of Targets: 3 |
| T3D1021 | Xylylcarb 2425-10-7 | C10H13NO2 179.216 g/mol |  |
| Xylylcarb is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites ...more Number of Targets: 2 |
| T3D0902 | 3,5-Dimethylphenyl methylcarbamate 2655-14-3 | C10H13NO2 179.216 g/mol |  |
| 3,5-Dimethylphenyl methylcarbamate is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoyla...more Number of Targets: 2 |