Browsing Toxins By Category
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2547 | Taicatoxin 112154-17-3 | Not Available 9711.255 g/mol |  |
| Taicatoxin blocks the voltage-dependent L-type calcium channels from the heart and on the small conductance calcium-activated potassium channels in the brain. (L1105) Number of Targets: 11 |
| T3D2549 | Eledoisin (Eledone cirrhosa) 69-25-0 | Not Available 1206.410 g/mol |  |
| Eledoisin is a tachykinin peptide. Tachykinins excite neurons, evoke behavioural responses, are potent vasodilators and secretagogues, and contract (directly or indire...more Number of Targets: 3 |
| T3D2552 | Sticholysin 269658-04-0; 183449-91-4 | Not Available 19390.885 g/mol |  |
| Sticholysin is a cardiac stimulatory and hemolytic pore-forming protein. Pore formation likely proceeds by membrane binding via a surface rich in aromatic residues, fo...more Number of Targets: 0 |
| T3D2580 | Mastoparan (Vespa tropica) 72093-21-1 | Not Available 1625.055 g/mol |  |
| Mastoparan causes varying types of exocytosis, depending on its location. In mast cells it causes histamine secretion, while in platelets and chromaffin cells the rele...more Number of Targets: 0 |
| T3D2581 | Hongotoxin 203526-59-4 | Not Available 4226.080 g/mol |  |
| Hongotoxin inhibits voltage-gated potassium channels. (L1049) Number of Targets: 4 |
| T3D2582 | Maurocalcin 269745-22-4 | Not Available 3864.570 g/mol |  |
| Maurocalcin potently and reversibly modifies channel gating behaviour of the type 1 ryanodine receptor by inducing prominent subconductance behaviour. (T170) Number of Targets: 1 |
| T3D2584 | Myotoxin (Crotalus viridis viridis) 132821-30-8 | Not Available 4827.755 g/mol |  |
| Myotoxins work by a non-enzymatic mechanism that leads to severe muscle necrosis, causing paralysis and eventually death. They may also modify voltage-sensitive sodium...more Number of Targets: 14 |
| T3D2585 | Taipoxin 52019-39-3 | Not Available 13828.660 g/mol |  |
| Taipoxin causes a gradual reduction to complete stop of evoked and spontaneous release of acetylcholine from motor nerve terminals. (L1106) Number of Targets: 0 |
| T3D2589 | Anthopleurin (Anthopleura xanthogrammica) 600880-63-9 | Not Available 5137.770 g/mol |  |
| Anthopleurin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of m...more Number of Targets: 14 |
| T3D2590 | Calitoxin 118354-83-9 | Not Available 8727.960 g/mol | |
| Calitoxin binds specifically to the voltage-gated sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mamm...more Number of Targets: 14 |
| T3D2592 | Edema factor 921236-86-4 | Not Available 92477.285 g/mol |  |
| After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more Number of Targets: 7 |
| T3D2593 | Protective antigen 643772-15-0 | Not Available 85810.325 g/mol |  |
| After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more Number of Targets: 7 |
| T3D2594 | Lethal factor 159233-86-0 | Not Available 93769.580 g/mol |  |
| After binding to a host cell surface receptor, PA is cleaved by membrane endoproteases of the furin family. Cleaved PA molecules assemble into heptamers, which then as...more Number of Targets: 7 |
| T3D2595 | Pertussis toxin 70323-44-3 | Not Available 29973.970 g/mol |  |
| After binding to the cell receptors, pertussis toxin (PTX) is endocytosed and the A moiety translocates into the cytosol where it expresses the ADP-ribosyltransferase ...more Number of Targets: 6 |
| T3D2596 | Bifunctional hemolysin/adenylate cyclase (Bordetella pertussis) 566070-83-5 | Not Available 177519.955 g/mol |  |
| After binding of the pertussis AC toxin to the cell, binding to calcium ions leads to the translocation of its adenylate cyclase domain into the cytoplasm, where, upon...more Number of Targets: 1 |
| T3D2597 | Toxin A (Clostridium difficile) Not Available | Not Available 308052.765 g/mol |  |
| Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more Number of Targets: 20 |
| T3D2598 | Toxin B (Clostridium difficile) Not Available | Not Available 269709.285 g/mol |  |
| Rho GTPases are activated by glucosylation (for example RhoA at Thr37). The toxins catalyze the transfer of a glucosyl moiety from UDP-glucose to the Rho GTPases. The ...more Number of Targets: 20 |
| T3D2599 | Alpha-toxin (Clostridium perfringens) Not Available | Not Available 45529.285 g/mol |  |
| Clostridium perfringens alpha toxin is a zinc metallophospholipase requiring zinc for activation. The C-terminal C2-like PLAT domain binds calcium and allows the toxin...more Number of Targets: 1 |
| T3D2600 | Heat-labile enterotoxin (Escherichia coli) Not Available | Not Available 35330.140 g/mol |  |
| Through ADP-ribosylation of a G-protein, heat-labile enterotoxin stimulates adenylate cyclase leading to increased cAMP in epithelial cells. Elevated cAMP levels stimu...more Number of Targets: 2 |
| T3D2601 | Perfringolysin O 71329-60-7 | Not Available 55829.405 g/mol |  |
| Perfringolysin O binds to cholesterol on eukaryotic cell membranes, then forms oligomeric pores. This causes membrane damage and lysis of the cell. (A2832) Number of Targets: 1 |
| T3D2602 | Tetanus toxin 676570-37-9 | Not Available 150680.980 g/mol |  |
| The bacterium synthesizes the tetanus toxin as a single 150kDa polypeptide chain (called the progenitor toxin), that is cleaved extracellularly by a bacterial protease...more Number of Targets: 1 |
| T3D2605 | Listeriolysin O 112627-82-4 | Not Available 58687.670 g/mol |  |
| Listeriolysin O is a thiol-activated cholesterol-dependent pore forming toxin protein. LLO is selectively activated within the acidic phagosomes of cells that have pha...more Number of Targets: 1 |
| T3D2606 | Dermonecrotic toxin (Pasteurella multocida) Not Available | Not Available 146382.000 g/mol |  |
| Stimulation of several signalling pathways is induced by PMT. Most remarkable is a potent mitogenic effect. Phospholipase C-beta and the small GTPase Rho are activated...more Number of Targets: 5 |
| T3D2607 | Exotoxin A (Pseudomonas aeruginosa) Not Available | Not Available 69283.345 g/mol |  |
| Pseudomonas exotoxin has exactly the same mechanism of action as the diphtheria toxin; it causes the ADP ribosylation of eucaryotic elongation factor 2 resulting in in...more Number of Targets: 1 |
| T3D2609 | Shiga toxin subunit A Not Available | Not Available 34813.360 g/mol |  |
| Shiga toxin causes the glycosidase cleavage of ribosomal eucaryotic 28S rRNA, resulting in inhibition of protein synthesis in susceptible cells. (L1767) Number of Targets: 1 |