Browsing Toxins By Category
Displaying toxin 3576 - 3600 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D1993 | 2,2',3,3',4,5',6,6'-Octabromobiphenyl 69887-11-2 | C12H2Br8 785.376 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |
| T3D0362 | Mercuric potassium iodide 7783-33-7 | HgI4K2 786.400 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D2467 | Phalloidin 17466-45-4 | Not Available 3301.700 g/mol |  |
| It binds actin, preventing its depolymerization and poisoning the cell. Phalloidin binds specifically at the interface between F-actin subunits, locking adjacent subun...more Number of Targets: 6 |
| T3D4864 | Erioglaucine A disodium salt 3844-45-9 | C37H34N2Na2O9S3 792.848 g/mol |  |
| Not Available Number of Targets: 5 |
| T3D1547 | Aluminum palmitate 555-35-1 | C48H93AlO6 793.230 g/mol |  |
| The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphoru...more Number of Targets: 3 |
| T3D2043 | 2,3,3',4,4',5,5',6'-Octabromobiphenyl Ether 32536-52-0 | C12H2Br8O 801.376 g/mol |  |
| Like other halogenated aromatic hydrocarbons, polybrominated diphenyl ethers bind to the cellular aryl hydrocarbon receptor (AhR), which regulates the synthesis of a v...more Number of Targets: 6 |
| T3D4732 | Tacrolimus 104987-11-3 | C44H69NO12 804.018 g/mol |  |
| The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in ato...more Number of Targets: 1 |
| T3D2470 | Phallisin 19774-69-7 | C35H48N8O12S 804.867 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D4029 | Okadaic acid 78111-17-8 | C44H68O13 805.003 g/mol |  |
| Okadaic acid (OA) dramatically increases both nerve growth factor (NGF) mRNA content (50-fold) and NGF secretion (100-fold) in astrocytes. Okadaic acid also activated ...more Number of Targets: 1 |
| T3D1331 | Lead subacetate 1335-32-6 | C4H10O8Pb3 807.700 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D3501 | Docetaxel 114977-28-5 | C43H53NO14 807.879 g/mol |  |
| Docetaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, docetaxel arrest...more Number of Targets: 9 |
| T3D4017 | Vinblastine 865-21-4 | C46H58N4O9 810.974 g/mol |  |
| The antitumor activity of vinblastine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Vinblastine binds to t...more Number of Targets: 6 |
| T3D0333 | Lead phosphate 7446-27-7 | O8P2Pb3 811.500 g/mol |  |
| Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more Number of Targets: 29 |
| T3D3536 | Telithromycin 191114-48-4 | C43H65N5O10 812.004 g/mol |  |
| Telithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positi...more Number of Targets: 6 |
| T3D1900 | Tris(4-bromophenyl)aminium hexachloroantimonate 24964-91-8 | C18H12Br3Cl6NSb 816.480 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D4030 | Dinophysistoxin 1 81720-10-7 | C45H70O13 819.030 g/mol |  |
| Dinophysistoxin 1 (DTX1) is the analogue of okadaic acid causing diarrheic shellfish poisoning (DSP) in humans shortly after the ingestion of contaminated seafood. DTX...more Number of Targets: 0 |
| T3D2969 | Rifampin 13292-46-1 | C43H58N4O12 822.940 g/mol |  |
| Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. Number of Targets: 10 |
| T3D4447 | Propionyl-CoA 317-66-8 | C24H40N7O17P3S 823.597 g/mol |  |
| In propionic aciduria, propionyl CoA accumulates within the mitochondria in massive quantities; free carnitine is then esterified, creating propionyl carnitine, which ...more Number of Targets: 0 |
| T3D4016 | Vincristine 57-22-7 | C46H56N4O10 824.958 g/mol |  |
| The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkal...more Number of Targets: 7 |
| T3D3616 | Nodularin-R 118399-22-7 | C41H60N8O10 824.963 g/mol |  |
| The site of action of microcystins is the hepatocyte, the commonest cell type in the liver. They act by disrupting the cytoskeleton, the adaptable protein framework th...more Number of Targets: 23 |
| T3D3098 | Alcuronium 23214-96-2 | C44H50Br2N4O2 826.701 g/mol |  |
| Curare is a non-depolarizing muscle relaxant that acts as a competitive antagonist at the nicotinic acetylcholine receptors. (L1256) Number of Targets: 17 |
| T3D4322 | Uroporphyrin III 18273-06-8 | C40H38N4O16 830.747 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D4324 | Uroporphyrin I 607-14-7 | C40H38N4O16 830.747 g/mol |  |
| Not Available Number of Targets: 0 |
| T3D2472 | Phallacin 53568-40-4 | C37H50N8O12S 830.904 g/mol |  |
| Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent sub...more Number of Targets: 6 |
| T3D2672 | Azaspiracid 214899-21-5 | C47H71NO12 842.066 g/mol |  |
| Azaspiracid-4 dose-dependent inhibits the increase in cytosolic Ca2+ levels induced by thapsigargin (Tg) (A330). Azaspiracid-2 and Azaspiracid-3 clearly increase cytos...more Number of Targets: 1 |