Browsing Toxins By Category
Displaying toxin 376 - 400 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D2242 | 2,3,7,8-Tetrabromodibenzofuran 67733-57-7 | C12H4Br4O 483.776 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D2188 | 1,2,7,8-Tetrabromodibenzofuran 84761-80-8 | C12H4Br4O 483.776 g/mol |  |
| Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso...more Number of Targets: 2 |
| T3D3679 | Cytochalasin E 36011-19-5 | C27H33NO7 483.553 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D3898 | Penoxsulam 219714-96-2 | C16H14F5N5O5S 483.370 g/mol |  |
| Not Available Number of Targets: 7 |
| T3D3683 | Dihydrocytochalasin B gamma-lactone 14110-71-5 | C29H39NO5 481.624 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D2680 | Rosuvastatin 287714-41-4 | C22H28FN3O6S 481.538 g/mol |  |
| Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in chole...more Number of Targets: 3 |
| T3D1829 | Antimony triselenide 1315-05-5 | Sb2Se3 480.400 g/mol |  |
| Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ...more Number of Targets: 20 |
| T3D3667 | Cytochalasin B 14930-96-2 | C29H37NO5 479.608 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 7 |
| T3D3743 | Fumitremorgin B 12626-17-4 | C27H33N3O5 479.568 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 23 |
| T3D3676 | Cytochalasin A 14110-64-6 | C29H35NO5 477.592 g/mol |  |
| Cytochalasins are known to bind to the barbed, fast growing plus ends of microfilaments, which then blocks both the assembly and disassembly of individual actin monome...more Number of Targets: 6 |
| T3D3751 | Aurovertin D 65256-31-7 | C25H32O9 476.516 g/mol |  |
| Aurovertins are a mixed, noncompetitive inhibitors of both ATP hydrolysis and synthesis. They do this by inhibiting the proton-pumping F1F0-ATP synthase by binding to ...more Number of Targets: 1 |
| T3D3803 | Butafenacil 134605-64-4 | C20H18ClF3N2O6 474.815 g/mol |  |
| Not Available Number of Targets: 16 |
| T3D3657 | Diundecyl phthalate 3648-20-2 | C30H50O4 474.716 g/mol |  |
| Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr...more Number of Targets: 0 |
| T3D0299 | Zinc arsenate 13464-44-3 | As2O8Zn3 474.065 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 45 |
| T3D3776 | Sporidesmin 1456-55-9 | C18H20ClN3O6S2 473.951 g/mol |  |
| Sporidesmin and its reduced (dithiol) form undergo cyclic reduction/autoxidation reactions with glutathione and other thiols, generating toxic superoxide radicals, hyd...more Number of Targets: 0 |
| T3D2849 | Pteroyl-D-glutamic acid 1492-18-8 | C20H23N7O7 473.439 g/mol |  |
| As leucovorin is a derivative of folic acid, it can be used to increase levels of folic acid under conditions favoring folic acid inhibition (following treatment of fo...more Number of Targets: 1 |
| T3D0343 | Mercury(I) chloride 10112-91-1 | Cl2Hg2 472.090 g/mol |  |
| High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more Number of Targets: 50 |
| T3D2757 | Terfenadine 50679-08-8 | C32H41NO2 471.673 g/mol |  |
| Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of ter...more Number of Targets: 11 |
| T3D1893 | Triphenylantimony diacetate 1538-62-1 | C22H21O4Sb 471.160 g/mol |  |
| The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes...more Number of Targets: 20 |
| T3D1399 | Potassium cobaltinitrite 13782-01-9 | CoH2K3N6O13 470.276 g/mol |  |
| Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, c...more Number of Targets: 44 |
| T3D1798 | Dibrompropamidine 496-00-4 | C17H18Br2N4O2 470.158 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 3 |
| T3D2995 | Nefazodone 83366-66-9 | C25H32ClN5O2 470.007 g/mol |  |
| Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT2) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibit...more Number of Targets: 14 |
| T3D2035 | 2,2',3,3'-Tetrabromobiphenyl Not Available | C12H6Br4 469.792 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 0 |
| T3D2033 | 2,2',3,6-Tetrabromobiphenyl Not Available | C12H6Br4 469.792 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 0 |
| T3D2026 | 2,3,3',4-Tetrabromobiphenyl 97038-99-8 | C12H6Br4 469.792 g/mol |  |
| The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR...more Number of Targets: 1 |