Somatostatin receptor type 4

NameSomatostatin receptor type 4
Synonyms
  • SS-4-R
Gene NameSSTR4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013742|Somatostatin receptor type 4
MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLV
GLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCR
AVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP
IAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRA
VALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILS
YANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCM
CPPLPCQQEALQPEPGRKRIPLTRTTTF
Number of residues388
Molecular Weight42002.245
Theoretical pINot Available
GO Classification
Functions
  • somatostatin receptor activity
  • neuropeptide binding
Processes
  • negative regulation of cAMP metabolic process
  • neuropeptide signaling pathway
  • synaptic transmission
  • cell migration
  • negative regulation of cell proliferation
  • G-protein coupled receptor signaling pathway
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • arachidonic acid metabolic process
  • forebrain development
  • positive regulation of MAPK cascade
  • cellular response to glucocorticoid stimulus
  • somatostatin signaling pathway
Components
  • plasma membrane
  • integral component of plasma membrane
  • neuron projection
  • cytoplasm
General FunctionSomatostatin receptor activity
Specific FunctionReceptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
Pfam Domain Function
Transmembrane Regions47-73 84-104 121-142 162-185 209-232 261-280 292-314
GenBank Protein IDNot Available
UniProtKB IDP31391
UniProtKB Entry NameSSR4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013743|Somatostatin receptor type 4 (SSTR4)
ATGAGCGCCCCCTCGACGCTGCCCCCCGGGGGCGAGGAAGGGCTGGGGACGGCCTGGCCC
TCTGCAGCCAATGCCAGTAGCGCTCCGGCGGAGGCGGAGGAGGCGGTGGCGGGGCCCGGG
GACGCGCGGGCGGCGGGCATGGTCGCTATCCAGTGCATCTACGCGCTGGTGTGCCTGGTG
GGGCTGGTGGGCAACGCCCTGGTCATCTTCGTGATCCTTCGCTACGCCAAGATGAAGACG
GCTACCAACATCTACCTGCTCAACCTGGCCGTAGCCGACGAGCTCTTCATGCTGAGCGTG
CCCTTCGTGGCCTCGTCGGCCGCCCTGCGCCACTGGCCCTTCGGCTCCGTGCTGTGCCGC
GCGGTGCTCAGCGTCGACGGCCTCAACATGTTCACCAGCGTCTTCTGTCTCACCGTGCTC
AGCGTGGACCGCTACGTGGCCGTGGTGCACCCTCTGCGCGCGGCGACCTACCGGCGGCCC
AGCGTGGCCAAGCTCATCAACCTGGGCGTGTGGCTGGCATCCCTGTTGGTCACTCTCCCC
ATCGCCATCTTCGCAGACACCAGACCGGCTCGCGGCGGCCAGGCCGTGGCCTGCAACCTG
CAGTGGCCACACCCGGCCTGGTCGGCAGTCTTCGTGGTCTACACTTTCCTGCTGGGCTTC
CTGCTGCCCGTGCTGGCCATTGGCCTGTGCTACCTGCTCATCGTGGGCAAGATGCGCGCC
GTGGCCCTGCGCGCTGGCTGGCAGCAGCGCAGGCGCTCGGAGAAGAAAATCACCAGGCTG
GTGCTGATGGTCGTGGTCGTCTTTGTGCTCTGCTGGATGCCTTTCTACGTGGTGCAGCTG
CTGAACCTCTTCGTGACCAGCCTTGATGCCACCGTCAACCACGTGTCCCTTATCCTTAGC
TATGCCAACAGCTGCGCCAACCCCATTCTCTATGGCTTCCTCTCCGACAACTTCCGCCGA
TTCTTCCAGCGGGTTCTCTGCCTGCGCTGCTGCCTCCTGGAAGGTGCTGGAGGTGCTGAG
GAGGAGCCCCTGGACTACTATGCCACTGCTCTCAAGAGCAAAGGTGGGGCAGGGTGCATG
TGCCCCCCACTCCCCTGCCAGCAGGAAGCCCTGCAACCAGAACCCGGCCGCAAGCGCATC
CCCCTCACCAGGACCACCACCTTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11333
Chromosome Location20
LocusNot Available
References
  1. Xu Y, Song J, Bruno JF, Berelowitz M: Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Biochem Biophys Res Commun. 1993 Jun 15;193(2):648-52. 8512564
  2. Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R: Cloning and characterization of a fourth human somatostatin receptor. Proc Natl Acad Sci U S A. 1993 May 1;90(9):4196-200. 8483934
  3. Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, Ihara Y, Li Q, Imura H, Seino S, et al.: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. Biochem Biophys Res Commun. 1993 Sep 15;195(2):844-52. 8373420
  4. Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB: Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol Pharmacol. 1993 Jun;43(6):894-901. 8100352
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