- Effect
- Upregulated
- Gene
- glutamate-cysteine ligase, catalytic subunit
- Gene Symbol
- GCLC
- Gene ID
- 2729
- Interaction
- Thioctic Acid results in increased expression of GCLC mRNA
- Chromosome
- 6p12
References
- Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS: (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4302-10. [16249512 ]
- Jia Z, Hallur S, Zhu H, Li Y, Misra HP: Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity. Neurochem Res. 2008 May;33(5):790-800. Epub 2007 Oct 17. [17940886 ]