Browsing Toxins By Category
Displaying toxin 576 - 600 of 3678 in total
| T3DB ID | Name CAS Number | Formula Weight | Structure | Type | Mechanism of Toxicity |
|---|---|---|---|---|---|
| T3D3781 | Verrucosidin 88389-71-3 | C24H32O6 416.507 g/mol |  |
| Tremorgenic mycotoxins exert their toxic effects by interfering with neurotransmitter release, possibly by causing degeneration of nerve terminals. They are thought to...more Number of Targets: 23 |
| T3D2532 | Arenobufagin 464-74-4 | C24H32O6 416.507 g/mol |  |
| Arenobufagin blocks the sodium/potassium pump in heart tissue. (L1078) Number of Targets: 8 |
| T3D1034 | Cypermethrin 52315-07-8 | C22H19Cl2NO3 416.297 g/mol |  |
| Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th...more Number of Targets: 40 |
| T3D2988 | Miconazole 22916-47-8 | C18H14Cl4N2O 416.129 g/mol |  |
| Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fun...more Number of Targets: 17 |
| T3D1255 | Di-n-octyltin dichloride 3542-36-7 | C16H34Cl2Sn 416.060 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D4734 | Salmeterol 89365-50-4 | C25H37NO4 415.566 g/mol |  |
| Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the mol...more Number of Targets: 1 |
| T3D4232 | Cylindrospermopsin 143545-90-8 | C15H21N5O7S 415.422 g/mol |  |
| Not Available Number of Targets: 1 |
| T3D1165 | Uranium pentachloride 13470-21-8 | Cl5U 415.297 g/mol |  |
| Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot...more Number of Targets: 1 |
| T3D4912 | Ascorbyl palmitate 137-66-6 | C22H38O7 414.533 g/mol |  |
| Not Available Number of Targets: 2 |
| T3D2758 | Diltiazem 42399-41-7 | C22H26N2O4S 414.518 g/mol |  |
| Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem,...more Number of Targets: 6 |
| T3D4617 | Podofilox 477-47-4 | C22H22O8 414.405 g/mol |  |
| Etoposide, a semisynthetic derivative of podofilox, induces DNA breakage through its inhibition of topoisomerase II. The drug is most active in the late S and early G2...more Number of Targets: 7 |
| T3D2556 | Flecainide 54143-55-4 | C17H20F6N2O3 414.343 g/mol |  |
| Flecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions ...more Number of Targets: 4 |
| T3D3985 | Perfluorooctanoic acid 335-67-1 | C8HF15O2 414.068 g/mol |  |
| Not Available Number of Targets: 11 |
| T3D4531 | Pyraflufen-ethyl 129630-19-9 | C15H13Cl2F3N2O4 413.176 g/mol |  |
| Not Available Number of Targets: 14 |
| T3D0966 | Fenasulam 78357-48-9 | C17H17ClN2O6S 412.845 g/mol |  |
| Fenasulam is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites ...more Number of Targets: 2 |
| T3D1769 | Ytterbium(III) bromide 13759-89-2 | Br3Yb 412.750 g/mol |  |
| Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and...more Number of Targets: 6 |
| T3D3062 | Calcipotriol 112965-21-6 | C27H40O3 412.605 g/mol |  |
| The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it has been shown to have comparable affinity with calcitriol for the Vit...more Number of Targets: 1 |
| T3D4673 | Adapalene 106685-40-9 | C28H28O3 412.520 g/mol |  |
| Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor prot...more Number of Targets: 6 |
| T3D3090 | Grayanotoxin I 4720-09-6 | C22H36O7 412.517 g/mol |  |
| Grayanotoxins bind to specific sodium ion channels in cell membranes. The grayanotoxins prevent inactivation, leaving excitable cells depolarized. (L1251) Number of Targets: 14 |
| T3D3805 | Carfentrazone-ethyl 128639-02-1 | C15H14Cl2F3N3O3 412.191 g/mol |  |
| Not Available Number of Targets: 8 |
| T3D1260 | (Acetyloxy)triphenylstannane 900-95-8 | C20H21O2Sn 412.090 g/mol |  |
| Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas...more Number of Targets: 12 |
| T3D0031 | Toxaphene 8001-35-2 | C10H8Cl8 411.795 g/mol |  |
| Toxaphene is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinester...more Number of Targets: 52 |
| T3D1022 | Telodrin 297-78-9 | C9H4Cl8O 411.751 g/mol |  |
| It antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chlori...more Number of Targets: 38 |
| T3D1463 | Zinc phenolsulfate 127-82-2 | C12H10O8S2Zn 411.742 g/mol |  |
| Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unba...more Number of Targets: 1 |
| T3D4082 | Cyclopamine 4449-51-8 | C27H41NO2 411.620 g/mol |  |
| Cyclopamine causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single e...more Number of Targets: 2 |