S-phase kinase-associated protein 1

NameS-phase kinase-associated protein 1
Synonyms
  • Cyclin-A/CDK2-associated protein p19
  • EMC19
  • OCP-2
  • OCP-II
  • OCP2
  • Organ of Corti protein 2
  • Organ of Corti protein II
  • p19A
  • p19skp1
  • RNA polymerase II elongation factor-like protein
  • SIII
  • SKP1A
  • TCEB1L
  • Transcription elongation factor B polypeptide 1-like
Gene NameSKP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007229|S-phase kinase-associated protein 1
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ
WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC
KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
Number of residues163
Molecular Weight18657.86
Theoretical pI4.15
GO Classification
Functions
  • ubiquitin-protein transferase activity
Processes
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  • protein ubiquitination
  • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • tumor necrosis factor-mediated signaling pathway
  • MyD88-dependent toll-like receptor signaling pathway
  • histone H2A monoubiquitination
  • MyD88-independent toll-like receptor signaling pathway
  • innate immune response
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • stress-activated MAPK cascade
  • Fc-epsilon receptor signaling pathway
  • toll-like receptor 10 signaling pathway
  • stimulatory C-type lectin receptor signaling pathway
  • toll-like receptor 2 signaling pathway
  • circadian rhythm
  • toll-like receptor 3 signaling pathway
  • G2/M transition of mitotic cell cycle
  • toll-like receptor 4 signaling pathway
  • mitotic cell cycle
  • toll-like receptor 5 signaling pathway
  • G1/S transition of mitotic cell cycle
  • toll-like receptor 9 signaling pathway
  • T cell receptor signaling pathway
  • toll-like receptor signaling pathway
  • Notch signaling pathway
  • toll-like receptor TLR1
  • viral process
  • toll-like receptor TLR6
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • NIK/NF-kappaB signaling
  • TRIF-dependent toll-like receptor signaling pathway
Components
  • cytosol
  • Cul7-RING ubiquitin ligase complex
  • extracellular exosome
  • SCF ubiquitin ligase complex
  • nucleoplasm
General FunctionUbiquitin-protein transferase activity
Specific FunctionEssential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID995824
UniProtKB IDP63208
UniProtKB Entry NameSKP1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0017221|S-phase kinase-associated protein 1 (SKP1)
ATGCCTTCAATTAAGTTGCAGAGTTCTGATGGAGAGATATTTGAAGTTGATGTGGAAATT
GCCAAACAATCTGTGACTATTAAGACCATGTTGGAAGATTTGGGAATGGATGATGAAGGA
GATGATGACCCAGTTCCTCTACCAAATGTGAATGCAGCAATATTAAAAAAGGTCATTCAG
TGGTGCACCCACCACAAGGATGACCCTCCTCCTCCTGAAGATGATGAGAACAAAGAAAAG
CGAACAGATGATATCCCTGTTTGGGACCAAGAATTCCTGAAAGTTGACCAAGGAACACTT
TTTGAACTCATTCTGGCTGCAAACTACTTAGACATCAAAGGTTTGCTTGATGTTACATGC
AAGACTGTTGCCAATATGATCAAGGGGAAAACTCCTGAGGAGATTCGCAAGACCTTCAAT
ATCAAAAATGACTTTACTGAAGAGGAGGAAGCCCAGGTAGGTAGCACACAGTTTTGTCTT
TGA
GenBank Gene IDU33760
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10899
Chromosome Location5
Locus5q31
References
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  8. : . ;():. 9031623
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