Voltage-dependent anion-selective channel protein 2

NameVoltage-dependent anion-selective channel protein 2
Synonyms
  • Outer mitochondrial membrane protein porin 2
  • VDAC-2
Gene NameVDAC2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037860|Voltage-dependent anion-selective channel protein 2
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNT
DTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGK
KSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNF
AVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDP
TASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
Number of residues294
Molecular Weight31566.265
Theoretical pI6.76
GO Classification
Functions
  • porin activity
  • voltage-gated anion channel activity
  • nucleotide binding
Processes
  • negative regulation of intrinsic apoptotic signaling pathway
  • regulation of anion transmembrane transport
  • negative regulation of protein polymerization
  • anion transport
Components
  • mitochondrial outer membrane
  • extracellular exosome
  • myelin sheath
  • membrane raft
  • pore complex
  • mitochondrial nucleoid
  • mitochondrion
  • nucleus
  • mitochondrial inner membrane
General FunctionVoltage-gated anion channel activity
Specific FunctionForms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Pfam Domain Function
Transmembrane Regions37-46 50-58 65-75 80-87 91-100 106-115 122-131 134-141 148-156 161-169 174-186 189-196 200-209 213-222 229-238 242-249 253-262 265-274 284-293
GenBank Protein IDNot Available
UniProtKB IDP45880
UniProtKB Entry NameVDAC2_HUMAN
Cellular LocationMitochondrion outer membrane
Gene sequence
>lcl|BSEQ0019297|Voltage-dependent anion-selective channel protein 2 (VDAC2)
ATGAGCTGGTGTAATGAGCTCAGATTGCCTGCCCTTAAGCAGCACAGCATTGGCCGAGGA
CTTGAGAGTCACATTACAATGTGTATTCCTCCATCATATGCTGACCTTGGCAAAGCTGCC
AGAGATATTTTCAACAAAGGATTTGGTTTTGGGTTGGTGAAACTGGATGTGAAAACAAAG
TCTTGCAGTGGCGTGGAATTTTCAACGTCCGGTTCATCTAATACAGACACTGGTAAAGTT
ACTGGGACCTTGGAGACCAAATACAAGTGGTGTGAGTATGGTCTGACTTTCACAGAAAAG
TGGAACACTGATAACACTCTGGGAACAGAAATCGCAATTGAAGACCAGATTTGTCAAGGT
TTGAAACTGACATTTGATACTACCTTCTCACCAAACACAGGAAAGAAAAGTGGTAAAATC
AAGTCTTCTTACAAGAGGGAGTGTATAAACCTTGGTTGTGATGTTGACTTTGATTTTGCT
GGACCTGCAATCCATGGTTCAGCTGTCTTTGGTTATGAGGGCTGGCTTGCTGGCTACCAG
ATGACCTTTGACAGTGCCAAATCAAAGCTGACAAGGAATAACTTTGCAGTGGGCTACAGG
ACTGGGGACTTCCAGCTACACACTAATGTCAATGATGGGACAGAATTTGGAGGATCAATT
TATCAGAAAGTTTGTGAAGATCTTGACACTTCAGTAAACCTTGCTTGGACATCAGGTACC
AACTGCACTCGTTTTGGCATTGCAGCTAAATATCAGTTGGATCCCACTGCTTCCATTTCT
GCAAAAGTCAACAACTCTAGCTTAATTGGAGTAGGCTATACTCAGACTCTGAGGCCTGGT
GTGAAGCTTACACTCTCTGCTCTGGTAGATGGGAAGAGCATTAATGCTGGAGGCCACAAG
GTTGGGCTCGCCCTGGAGTTGGAGGCTTAA
GenBank Gene IDL08666
GeneCard IDNot Available
GenAtlas IDVDAC2
HGNC IDHGNC:12672
Chromosome Location10
Locus10q22
References
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