Macrophage migration inhibitory factor

NameMacrophage migration inhibitory factor
Synonyms
  • 5.3.2.1
  • GIF
  • GLIF
  • Glycosylation-inhibiting factor
  • L-dopachrome isomerase
  • L-dopachrome tautomerase
  • MIF
  • MMIF
  • Phenylpyruvate tautomerase
Gene NameMIF
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020563|Macrophage migration inhibitory factor
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Number of residues115
Molecular Weight12476.19
Theoretical pI8.05
GO Classification
Functions
  • receptor binding
  • cytokine activity
  • cytokine receptor binding
  • dopachrome isomerase activity
  • phenylpyruvate tautomerase activity
  • chemoattractant activity
Processes
  • negative regulation of myeloid cell apoptotic process
  • positive regulation of MAP kinase activity
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of mature B cell apoptotic process
  • negative regulation of gene expression
  • inflammatory response
  • positive regulation of chemokine (C-X-C motif) ligand 2 production
  • protein homotrimerization
  • cell aging
  • positive regulation of arachidonic acid secretion
  • regulation of macrophage activation
  • cell proliferation
  • positive regulation of B cell proliferation
  • positive chemotaxis
  • DNA damage response, signal transduction by p53 class mediator
  • negative regulation of cell cycle arrest
  • negative regulation of cell aging
  • negative regulation of DNA damage response, signal transduction by p53 class mediator
  • innate immune response
  • negative regulation of cellular protein metabolic process
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of lipopolysaccharide-mediated signaling pathway
  • positive regulation of cytokine secretion
  • negative regulation of apoptotic process
  • positive regulation of myeloid leukocyte cytokine production involved in immune response
  • positive regulation of fibroblast proliferation
  • positive regulation of peptidyl-serine phosphorylation
  • positive regulation of prostaglandin secretion involved in immune response
  • positive regulation of phosphorylation
  • positive regulation of protein kinase A signaling
  • cell surface receptor signaling pathway
  • prostaglandin biosynthetic process
  • carboxylic acid metabolic process
Components
  • extracellular space
  • cell surface
  • vesicle
  • extracellular exosome
  • myelin sheath
  • nucleoplasm
  • cytoplasm
  • extracellular region
General FunctionReceptor binding
Specific FunctionPro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID188556
UniProtKB IDP14174
UniProtKB Entry NameMIF_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020564|Macrophage migration inhibitory factor (MIF)
ATGCCGATGTTCATCGTAAACACCAACGTGCCCCGCGCCTCCGTGCCGGACGGGTTCCTC
TCCGAGCTCACCCAGCAGCTGGCGCAGGCCACCGGCAAGCCCCCCCAGTACATCGCGGTG
CACGTGGTCCCGGACCAGCTCATGGCCTTCGGCGGCTCCAGCGAGCCGTGCGCGCTCTGC
AGCCTGCACAGCATCGGCAAGATCGGCGGCGCGCAGAACCGCTCCTACAGCAAGCTGCTG
TGCGGCCTGCTGGCCGAGCGCCTGCGCATCAGCCCGGACAGGGTCTACATCAACTATTAC
GACATGAACGCGGCCAATGTGGGCTGGAACAACTCCACCTTCGCCTAA
GenBank Gene IDM25639
GeneCard IDNot Available
GenAtlas IDMIF
HGNC IDHGNC:7097
Chromosome Location22
Locus22q11.23
References
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